Mitchell County is located less than 25 miles from Interstate-35 and business only has to travel 11 miles to reach Interstate 90 from its northern border.
The Avenue of the Saints is located 10 miles south of Mitchell County, giving access to Interstate 80 and St. Louis going south.
Two major railroads intersect Mitchell County, the IC & E Railroad and the Cedar Valley Railroad. Competing railroads make for good freight rates and these two lines are less than a mile apart in the far north end of Mitchell County.
The City of Osage houses an airport on the east end of the community with a 3400 foot long runway. The use of the hangar and pilot's lounge are available for visiting aircraft. Rochester, MN houses an international airport, which is just 60 minutes away from Mitchell County.